Doctor Baines has been conducting genetic experiments on piranhas and has made them virtually unstoppable. Unfortunately, his assistants, Maggie and Paul, accidentally release the hybrids into the Lost River Lake threatening to destroy everyone in their path. Can they prevent the flesh-eating piranhas from escaping into the ocean and spawning?
An overlooked pencil-pusher catches her husband in bed with another woman, the shock of which causes him to die of a heart attack. So she buries his body and takes advantage of the growing celebrity status that comes from having a missing husband. But she quickly finds herself in over her head, dodging cops and criminals, all while trying to keep the truth from her sister, a local news anchor who’s desperate for a story.
The major sub-plot circles around the youngest Griffin, Stewie, who has a near-death experience at a pool when a lifeguard chair falls on him, but he survives. After having a vision of being in Hell, he decides to change his ways, but this doesn't last long. While watching television, he and Brian spot a man that looks like Stewie. Brian is convinced that he is Stewie's real father, until Stewie learns that the man is actually himself as an adult, taking a vacation from his own time period. Baby Stewie visits thirty years later to discover that his adult self, going by the name Stu, is a single blue-collar middle-aged virgin working at a Circuit City-type store. Meanwhile, Peter and Lois are trying to teach their two older kids, Meg and Chris, to date. In the future, Chris, who hasn't changed much, is working as a cop and is married to a foul-mouthed hustler named Vanessa. Meg is now called Ron, since she had a sex-change after college. Written by pepperann210
Penurious but muscle-bound Blake Thorne has made a vast fortune marketing health food and health supplements. He once was a nice fellow, but as his wealth increases, he becomes increasingly self-centered and decadent. One day, he gets in a great paint-gun fight that goes too far. Blake escapes the cops by running into a shopping mall, quickly donning a Santa Suit and pretending to be St. Nick. A head injury causes Blake to suffer amnesia, and an opportunistic "elf" decides to convince Blake that he is indeed Santa. This leads "Santa" to help save an orphanage, filled with adorable moppets, from the machinations of a greedy, insane doctor.
Tony and Tina are excited to get married but they dread having the ceremony. Tina's mother and Tony's father used to be an item and neither parent has gotten over their bitter breakup. As everyone comes together to help plan the event, the parents cannot stop bickering and they are constantly at each other's throat. Adding to their woes are an eccentric photographer, a stubborn priest, unhappy bridesmaids and hung over groomsmen.