John Rambo is a US special forces veteran in Vietnam. He receives a message about the missing Gabriel, the daughter of his good friend. Rambo is convinced that this is the work of a well-known Mexico trafficking cartel. In despair, relatives ask for help from Rambo. Having collected all the military ammunition, he crosses the US-Mexican border, knowing full well that he is waiting for him insanely complex struggle with those for whom there are no rules.
In Mexico, SICARIO means hitman. In the lawless border area stretching between the U.S. and Mexico, an idealistic FBI agent (Emily Blunt) is enlisted by an elite government task force official (Josh Brolin) to aid in the escalating war against drugs. Led by an enigmatic consultant with a questionable past (Benicio Del Toro), the team sets out on a clandestine journey forcing Kate to question everything that she believes in order to survive.
The drug war on the US-Mexico border has escalated as the cartels have begun trafficking terrorists across the US border. To fight the war, federal agent Matt Graver re-teams with the mercurial Alejandro.