In a world where vampires walk the earth, Blade has a goal. His goal is to rid the world of all vampire evil. When Blade witnesses a vampire bite Dr. Karen Jenson, he fights away the beast and takes Jenson back to his hideout. Here, alongside Abraham Whistler, Blade attempts to help heal Jenson. The vampire Quinn who was attacked by Blade, reports back to his master Deacon Frost, who is planning a huge surprise for the human population.
The story follows a mother of two who inherits a home from her Aunt. On the first night in the new home she is confronted with murderous intruders and fights for her daughters lives. Sixteen years later when the daughters reunite at the house, and that is when things get strange.