This is a story about the battle for a hospital building in Grozny (Chechnya) in January 1995 between Russian Army forces and Chechen rebels supported by Arabian mujahideen and international mercenaries. Although the story is fictional, most of the characters are based on real-life prototypes and events are the compilation of true events during the Grozny Siege in the First Chechen War.
Combat has taken its toll on Rambo, but he's finally begun to find inner peace in a monastery. When Rambo's friend and mentor Col. Trautman asks for his help on a top secret mission to Afghanistan, Rambo declines but must reconsider when Trautman is captured.