London, England, 2008. Some of the most distinguished experts on the work of Italian artist Leonardo da Vinci (1452-1519) gather at the National Gallery to examine a painting known as Salvator Mundi; an event that turns out to be the first act of one of the most fascinating stories in the history of art.
Eddie Hawkins, called Hudson Hawk has just been released from ten years of prison and is planning to spend the rest of his life honestly. But then the crazy Mayflower couple blackmail him to steal some of the works of Leonardo da Vinci. If he refuses, they threaten to kill his friend Tommy.