After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
Bud and Doyle are two losers who are doing nothing with their lives. Both of their girlfriends are actively involved in saving the environment, but the two friends couldn't care less about saving the Earth. One day, when a group of scientists begin a mission to live inside a "Bio-Dome" for a year without outside contact, Bud and Doyle mistakenly become part of the project themselves.
A tenacious attorney uncovers a dark secret that connects a growing number of unexplained deaths due to one of the world's largest corporations. In the process, he risks everything — his future, his family, and his own life — to expose the truth.