Val has reached a place where he feels the only way out is to end things. But he considers himself a bit of a failure—his effectiveness lacking—so he figures he could use some help. As luck would have it, Val’s best friend, Kevin, is recovering from a failed suicide attempt, so he seems like the perfect partner for executing this double suicide plan. But before they go, they have some unfinished business to attend to.
A group of New Yorkers caught up in their romantic/sexual milieu converge at Shortbus, an underground Brooklyn salon infamous for its blend of art, music, politics, and carnality, and loosely inspired by various underground NYC gatherings that took place in the early 2000s. Here, gay couple Jamie and James meet Ceth, a young ex-model and aspiring singer.
A desperate man places a bizarre classified ad to end his life, but a strange turn of events occurs when an aimless girl decides to answer. As their lives collide, they realize the smallest choices can be the difference between life and death.
Guido Anselmi, a film director, finds himself creatively barren at the peak of his career. Urged by his doctors to rest, Anselmi heads for a luxurious resort, but a sorry group gathers—his producer, staff, actors, wife, mistress, and relatives—each one begging him to get on with the show. In retreat from their dependency, he fantasizes about past women and dreams of his childhood.