One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.
After having successfully eluded the authorities for years, Hannibal peacefully lives in Italy in disguise as an art scholar. Trouble strikes again when he's discovered leaving a deserving few dead in the process. He returns to America to make contact with now disgraced Agent Clarice Starling, who is suffering the wrath of a malicious FBI rival as well as the media.
A data courier, literally carrying a data package inside his head, must deliver it before he dies from the burden or is killed by the Yakuza. In a dystopian 2021, Johnny (Keanu Reeves) is a data trafficker who has an implant that allows him to securely store data too sensitive for regular computer networks. On one delivery run, he accepts a package that not only exceeds the implant's safety limits - and will kill him if the data is not removed in time - but also contains information far more important and valuable than he had ever imagined. On a race against time, he must avoid the assassins sent to kill him and remove the data before it, too, ends his life.