Two "down on their luck" buddies are convinced by a third to take a vacation. Only after landing in the third world country do they realize that they are there to attempt to capture the United States' most wanted criminal - with no military training.
After a mobster agrees to cooperate with an FBI investigation in order to stay out of prison, he's relocated by the authorities to a life of suburban anonymity as part of a witness protection program. It's not long before a couple of his new neighbours figure out his true identity and come knocking to see if he'd be up for one more hit—suburban style.
On the run after murdering a man, accountant William Blake encounters a strange North American man named Nobody who prepares him for his journey into the spiritual world.
Beck (The Rock) doesn't look for or try to make trouble for anyone. But trouble is what he's hired to clean up, and there's one final mess he's got to get out of before he can leave it all behind. And this one just keeps getting more and more tangled, like the Amazon jungle he's been sent to in The Rundown. At the center of his current trouble is a wise-ass named Travis (Scott), a fast-talking double dealer whose dad has commissioned Beck to retrieve from a lingering adventure in Brazil. Travis proves to be more of a handful than Beck expected, not only because of his mouth and his heels-dug-in reluctance to leave, but because of a couple of other complications he brings with him: Mariana (Dawson), a no-nonsense local who holds the answers to some of the jungle's hidden mysteries, and Hatcher (Walken), an unhinged despot who has turned the jungle and its inhabitants into his own fortune-making, gold-mining empire. Beck doesn't like to fight. But he's going to have to unleash everything he's got to keep on top of his smack-talking quarry, the girl with the secret, the crazy tyrant, the horny monkeys, the hallucinogenic fruit, the backs-to-the-wall rebels, the perilous terrain, the hidden traps and every other obstacle that this jungle throws at him.