When a mysterious spell transforms a young teenager's bratty little brother into a pig while their parents are on vacation, their only hope for restoring the hoofed youngster back to his human form is to take a trip south of the border in this supernatural comedy for the whole family starring Scarlett Johansson. For years, Kathy Cauldwell (Johansson) has been the target of younger brother George's obnoxious practical jokes. Soon after Kathy and George's parents leave the youngsters in the care of nanny Matilda (Eva Mendes) in order to get away for a much-needed vacation in France, George is transformed into a pig thanks to Matilda's ancient magical rocks. As the trio sets off to Mexico to seek the help of Matilda's Mexican grandmother with George's best friend Freud in tow (Alex D. Linz), matters are complicated when a local butcher sets his sights on the portly new ham in town.
Simon Phoenix, a violent criminal cryogenically frozen in 1996, escapes during a parole hearing in 2032 in the utopia of San Angeles. Police are incapable of dealing with his violent ways and turn to his captor, who had also been cryogenically frozen after being wrongfully accused of killing 30 innocent people while apprehending Phoenix.
Unlucky in love, chemist Paul Matthews visits gypsy Madame Rosa for help. Quickly realizing he is a hopeless nerd, she gifts him with Love Potion No. 8, which makes anyone who wears it irresistible to the opposite sex for four hours. Paul and animal psychologist coworker Diane Farrow decide to test it on themselves. The awkward pair suddenly find themselves alluring to anyone they approach, but soon realize they are most attracted to each other.
A young man finds out that he holds the key to restoring hope and ensuring survival for the human race, while an alien species called the Drej are bent on mankind's destruction.
When a rare phenomenon gives police officer John Sullivan the chance to speak to his father, 30 years in the past, he takes the opportunity to prevent his dad's tragic death. After his actions inadvertently give rise to a series of brutal murders he and his father must find a way to fix the consequences of altering time.
A kindly occupational therapist undergoes a new procedure to be shrunken to four inches tall so that he and his wife can help save the planet and afford a nice lifestyle at the same time.