Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.
In New York in the late 60s, a politically motivated group of students plans bombings of company offices who do business with dictators in Middle American countries. But when they contact a known terrorist and bombing specialist, the FBI gets on their track.
Tiffany, Charlie and Vernon are con artists looking to up the ante from their typical scams. They figure a good way of doing this is taking down Dean "The Dean" Stevens, a well-known cardsharp, in a rigged game. However, they first need enough money to enter a game with Stevens, so they decide to strike a deal with fellow crook Larry Jennings to scam a local gangster -- which turns out to be a bad idea.
A woman who has recently discovered that she is the daughter of Angelo, a major mafia boss, decides to wreak vengeance when he is killed by a hitman. She's aided by his faithful bodyguard, with whom she soon falls in love.
Frank Leone is nearing the end of his prison term for a relatively minor crime. Just before he is paroled, however, Warden Drumgoole takes charge. Drumgoole was assigned to a hell-hole prison after his administration was publicly humiliated by Leone, and has now arrived on the scene to ensure that Leone never sees the light of day.
Assassin Robert Rath arrives at a funeral to kill a prominent mobster, only to witness a rival hired gun complete the job for him -- with grisly results. Horrified by the murder of innocent bystanders, Rath decides to take one last job and then return to civilian life. But finding his way out of the world of contract killing grows ever more dangerous as Rath falls for his female target and becomes a marked man himself.