In Paris, Ariane and Lena are sisters. Ariane writes photo novellas for the magazine "Toi et Moi." She's emotional and her long-time boyfriend, Farid, has her in a state because he won't propose, won't ask her to live with him, and often is unavailable. Lena is a cellist, quiet and circumspect in life and in her playing. She lives without passion with her boyfriend François; they're talking about having a baby.
In a desert town, sometime in the future, a repressive government regime restricts all forms of artistic expression. At night, Theo breaks the law, risking torture and death, to paint his work on public spaces. But when his lover Elia is arrested for committing the same crime, Theo allows himself to be captured hoping to somehow be reunited with her.
Aviator Marie Vallières de Beaumont goes on a journey to find her lover Bill Lancaster after his plane disappears in the Sahara. After her plane is forced down in the Ténéré she meets Lieutenant Antoine Chauvet of the French Camel Corps who joins in the hunt for Lancaster. As the two endure hardships in the desert, they begin to develop feelings for each other.
Malik (Omar Epps) is an African-American student attending on a track scholarship; academics are not his strong suit, and he goes in thinking that his athletic abilities will earn him a free ride through college. Fudge (Ice Cube), a "professional student" who has been at Columbus for six years so far, becomes friendly with Malik and challenges his views about race and politics in America.
Flighty Emily "Jacks" Jackson works for the British edition of Vogue magazine. Rather than pursue a relationship, Jacks regularly hooks up with her devoted ex-boyfriend, James Wildstone, and lives with Peter Simon, a gay screenwriter. When Jacks meets Argentinian photographer's assistant Paolo Sarmiento, she assumes he is gay and tries to bring him and Peter together, unaware that Paolo is straight and in love with her.
His wife having recently died, Thomas Jefferson accepts the post of United States ambassador to pre-revolutionary France, though he finds it difficult to adjust to life in a country where the aristocracy subjugates an increasingly restless peasantry. In Paris, he becomes smitten with cultured artist Maria Cosway, but, when his daughter visits from Virginia accompanied by her attractive slave, Sally Hemings, Jefferson's attentions are diverted.
Some thirty years after Arlis witnesses his father murdering a family, he runs into Kay, who happens to be the family's baby who was spared. Kay and Arlis suspect nothing about each other, but when his father returns, old wounds are reopened.
Aspiring architect Tom Thompson is told by mysterious Ruth Abernathy that his best friend, "Bill," has taken his own life. Except that Tom has never met Bill and neither have his incredulous friends. So when Tom foolishly agrees to give the eulogy at Bill's funeral, it sets him on a collision course with Ruth -- who is revealed to be Bill's oversexed mother -- and Julie DeMarco, the longtime crush Tom hasn't seen since they were teens.
Young Shakespeare is forced to stage his latest comedy, "Romeo and Ethel, the Pirate's Daughter," before it's even written. When a lovely noblewoman auditions for a role, they fall into forbidden love -- and his play finds a new life (and title). As their relationship progresses, Shakespeare's comedy soon transforms into tragedy.