Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.
Roger, a straight-laced politician has big plans to propose to his dream girl at her family's lake house. But everything goes awry when he meets his potential brother-in-law Todd: a full-time camp counselor with a heart of gold and a wild sense of fun, pining to be Roger's best friend, and ultimately catapulting him into a series of unfortunate events. As Roger tries to take a stand amidst outrageous fishing excursions, propulsive water jetpacks and American history-themed musicals, he realizes that being a part of a new family may be more difficult than he'd thought.
Advertising executive Nick Beame learns that his wife is sleeping with his employer. In a state of despair, he encounters a bumbling thief whose attempted carjacking goes awry when Nick takes him on an involuntary joyride. Soon the betrayed businessman and the incompetent crook strike up a partnership and develop a robbery-revenge scheme. But it turns out that some other criminals in the area don't appreciate the competition.
Auggie runs a small tobacco shop in Brooklyn, New York. The whole neighborhood comes to visit him to buy cigarettes and have some small talk. During the movie Lou Reed tries to explain why he has to have a cut on his health insurance bill if he keeps smoking and Madonna acts as a Singing Telegram.
After a car crash sends repressed cartoonist Stu Miley (Fraser) into a coma, he and the mischievous Monkeybone, his hilariously horny alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!
Leo Borlock is an average student at Mica High School. He gets decent grades, is a member of the school's marching band and has always been content flying under the radar. But all that changes when he meets Stargirl Caraway, a confident and colorful new student with a penchant for the ukulele, who stands out in a crowd. She is kind, finds magic in the mundane and touches the lives of others with the simplest of gestures. Her eccentricities and infectious personality charm Leo and the student body, and she quickly goes from being ignored and ridiculed to accepted and praised, then back again, sending Leo on a rollercoaster ride of emotions.
An eclectic band of misfits becomes an unlikely family as they take a wild journey in the name of love while on the run from an overzealous FBI duo who want them dead or alive - preferably dead.
A trio of beautiful girls set out to revolutionize life at a grungy American university: the dynamic leader Violet Wister, principled Rose and sexy Heather. They welcome transfer student Lily into their group which seeks to help severely depressed students with a program of good hygiene and musical dance numbers.
Ted Morgan has been treading water for most of his life. After his wife leaves him, Ted realizes he has nothing left to live for. Summoning the courage for one last act, Ted decides to go home and face the people he feels are responsible for creating the shell of a person he has become. But life is tricky. The more determined Ted is to confront his demons, to get closure, and to withdraw from his family, the more Ted is yanked into the chaos of their lives. So, when Ted Morgan decides to kill himself, he finds a reason to live.
Three provocative short stories. An American in Paris seduces a young man only to have the tables turned; a tourist recovering from an accident is alone but far from lonely; and an exchange student decides to intervene when he sees the woman in the opposite apartment being tied, gagged and beaten by her lover.