Nathalie and Jean-Pierre have been together for five years, to celebrate their anniversary, Jean-Pierre prepare a surprise present for his girlfriend: a cute four month english bullgod. Nathalie loves her present and calls the puppy "Tresor"; her relationship with the dog is close and strong since the begining but causes problems in the couple.
While a terrorist epidemy strikes the world leaders, the commissaire San-Antonio and his partner, the lieutenant Bérurier, have to escort the French ambassador in a British hotel. But after a negligence of Bérurier (one more little sex affair...), San-Antonio witnessed, helpless, to the ambassador's abduction, organized by a gorgeous Italian girl. Back to Paris, San-Antonio is dismissed by the police chief, Achille Hachille. A real godsend for Bérurier, who get promoted... But soon, the situation degenerates, when the president of the Republic mysteriously disappears. Immediate reaction from Police Minister : San-Antonio is the only one who can save the day. He has 48 hours and a secret squad to find the president. At the Elysée, San-Antonio finds Bérurier, the official investigator. But now, it's every man for himself : who will be the first to find the President ? There are multiple trails: terrorists, unscrupulous banks, international dealers, dishonest politicians, pretty woman with very convincing arguments.