Leonardo, a 19-year-old student, leaves his hometown of Palermo to study economics in London. He soon grows restless and enrolls at the University of Siena to study literature before dropping out of school to study classics on his own. The following year, he travels to Turin where he meets a man who will help him on his journey of self-discovery.
Nina, an OB-GYN, faces accusations after newborn's death. Her life undergoes scrutiny during investigation. She persists in her medical duties, determined to provide care others hesitate to offer, despite risks.
One day, Annabì decides it’s enough. Her whole life has been affected by her fear of flying and so has her career. She is a successful actress but has turned down many roles abroad because flying is an insurmountable obstacle for her. Now, her daughter Serena has decided to study in California. Obsessed with the idea of not being a good mother, Annabì forces herself to cross the dreaded threshold of Fiumicino airport and to head to a secluded area where a course will take place. Other mysterious travelers are heading to the same place, all of them with their own baggage of fears and willing to overcome their aerophobia.
Amanda, 24, lives mostly isolated and has never had any friends, even if it's the thing she wants the most. Amanda chooses her new mission as to convince her childhood friend to believe that they are still best friends.
Abandoned by her father, a young woman embarks on a thousand-mile odyssey through the backroads of America where she meets a disenfranchised drifter. But despite their best efforts, all roads lead back to their terrifying pasts and to a final stand that will determine whether their love can survive their otherness.