Edward O'Donnell is the name of: Edward Joseph O'Donnell (1931–2009), Roman Catholic Bishop of the Diocese of Lafayette, Louisiana Edward J. O'Donnell (1909–1986), President of Marquette University (1948–1962) Edward O'Donnell (bootlegger) (1890–1962), also known as "Spike" O'Donnell, Chicago gang leader during Prohibition (see List of American mobsters of Irish descent) Eddie O'Donnell (1887–1920), American race car driver