John Spence may refer to: John Spence (frogman) (1918–2013), American World War II veteran, first American combat frogman John Spence (musician) (1969–1987), founding member of the band No Doubt John Spence (politician) (1920–1986), British Conservative MP 1970–1986 John Spence (sailor) (1875–1946), British sailor, won silver medal at 1908 Summer Olympics John Spence (scientist) (1929–2013), Trinidadian botanist and politician John C. H. Spence, Richard Snell Professor of Physics at Arizona State University John S. Spence (1788–1840), American Senator from Maryland John Selby Spence (bishop) (1909–1973) John David Spence (born 1944), Canadian medical doctor, medical researcher and professor John Brodie Spence (c. 1824–1902), banker and politician in South Australia John Spence (footballer), footballer for Sunderland John Spence, a zoo director from South Africa