David Spence may refer to: David Spence (VC) (1818–1877), Scottish recipient of the Victoria Cross David Spence (Canadian politician) (1867–1940), member of the Canadian House of Commons Dave Spence (born 1958), candidate for governor in Missouri David Spence (Manitoba politician) (1824–1885), politician in Manitoba, Canada David Allan Spence (1926–2003), New Zealand and British mathematician David Spence (rubber chemistry) (1881–1957), pioneer in the field of rubber chemistry Dave Spence (cricketer) (born 1930), New Zealand cricketer David Jerome Spence (1873–1955), Canadian architect, designer of such buildings as Montreal's Martlet House David H. N. Spence (1925-1985) British botanist