There were five on her list. Now it's three. O-Ren Ishii and Vernita Green were the first to fall, now The Bride (Uma Thurman) is out to finish the job by killing Elle Driver, Budd, and last of all, Bill (David Carradine). If the final three aren't afraid now, they better start, because she's coming for them. However, something has thrown off her plans a bit. Her daughter (whom she was pregnant with as she was getting married) is still alive. What affect this will have on her quest for vengeance is unclear, but the question is, will The Bride have actually succeeded in completing her ultimate goal, to kill Bill?
A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.