Unlucky assassin Ladybug is determined to do his job peacefully after one too many gigs gone off the rails. Fate, however, may have other plans, as Ladybug's latest mission puts him on a collision course with lethal adversaries from around the globe—all with connected, yet conflicting, objectives—on the world's fastest train.
In the dark heart of a sprawling, anonymous city, two assassins carry out a sinister mission, a teacher battles a fatal illness, and an enigmatic janitor and a curious waitress lead dangerous double lives. Murderous consequences unravel in the dead of night, as their lives intertwine at the hands of a mysterious criminal mastermind who is hell-bent on revenge.
Walter Weed is an unassuming desk jockey at the FBI when the Bureau uncovers a plot to assassinate him. A team of degenerate, psychotic assassins dispatched by mystery man Hal Leuco to win a huge bounty includes a resourceful beauty who has a unique method of killing her prey, a power-tool wielding psychopath and a deadly master of disguise.
An important drug lord settled in Marseille is suspected of having ordered the killing of an American agent, but it is impossible to impute him due to his political influences, so the dead agent's boss decides to hire the services of a hitman to kill him.
A mysterious woman, known as Madame M, kidnaps forty pre-teen girls and transports them to a remote island to train them as the most deadly assassins. CIA operative Jack Chen follows the case for 6 years with no leads, but when a series of assassinations begin to occur, Jack suspects that Madame M is back in business.
When new kid in town Ed Wallis is given an assignment to interview an older person, he turns to his mysterious neighbor, Ashby Holt for help. That new connection leads to unexpected journeys for both of them, as Ashby – who turns out to be a retired CIA assassin – deals with a terminal prognosis, and Ed deals with adjusting to life with his newly single mom and developing relationship with a brainy classmate, Eloise.