After the events at Lake Victoria, the prehistoric school of blood-thirsty piranhas make their way into swimming pools, plumbing, and a newly opened water park.
Doctor Baines has been conducting genetic experiments on piranhas and has made them virtually unstoppable. Unfortunately, his assistants, Maggie and Paul, accidentally release the hybrids into the Lost River Lake threatening to destroy everyone in their path. Can they prevent the flesh-eating piranhas from escaping into the ocean and spawning?
Every year the population of sleepy Lake Victoria explodes from 2,000 to 20,000 for Spring Break, a riot of sun and drunken fun. But this year, there's something more to worry about than hangovers and complaints from local old timers; a new type of terror is about to be cut loose on Lake Victoria. After a sudden underwater tremor sets free scores of the prehistoric man-eating fish, an unlikely group of strangers must band together to stop themselves from becoming fish food for the areas new razor-toothed residents.
Cast: Richard Dreyfuss, Ving Rhames, Eli Roth, Jessica Szohr, Elisabeth Shue
Directed by Alexandre Aja
Script: Josh Stolberg