An adorable group of talking baby-detectives travel to the deserts of Egypt to track down the naughty baby-criminal mastermind, "Big Baby," and his partner, the super-villain "Moriarty."
Hidden beneath Bobbins Daycare in Washington DC is the top-secret headquarters of The Baby Squad, where super genius babies use their secret baby language to solve mysteries all over the world.
Following on from the plot of the last movie, babies can communicate with each other using 'baby talk', and have an innate knowledge of the secrets of the universe. The baby geniuses become involved in a scheme by media mogul Bill Biscane (Jon Voight). Helping the geniuses is a legendary superbaby named Kahuna. He joins up with several other babies in an attempt to stop Biscane, who intends to use a state-of-the-art satellite system to control the world's population.