Celebrated heart surgeon Thomas Vrain supports the research of an offbeat scientist who has invented an artificial heart. Against the advice of the Ethics Committee, Dr. Vrain decides to perform the first artificial heart transplant.
Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.
Unemployed and recently dumped, Mitch and his buddy Sam start a revenge-for-hire business to raise the $50,000 that Sam's father needs to get a heart transplant. The dirty duo brings down a movie theater manager and hires hookers to pose as dead bodies during a live TV ad. When a wealthy developer hires the guys to trash a building (so that he can have it condemned), problems arise and a feud ensues.