When timid bank clerk Stanley Ipkiss discovers a magical mask containing the spirit of the Norse god Loki, his entire life changes. While wearing the mask, Ipkiss becomes a supernatural playboy exuding charm and confidence which allows him to catch the eye of local nightclub singer Tina Carlyle. Unfortunately, under the mask's influence, Ipkiss also robs a bank, which angers junior crime lord Dorian Tyrell, whose goons get blamed for the heist.
When The Man in the Yellow Hat befriends Curious George in the jungle, they set off on a non-stop, fun-filled journey through the wonders of the big city toward the warmth of true friendship.