Based on the true story of would-be Brooklyn bank robbers John Wojtowicz and Salvatore Naturale. Sonny and Sal attempt a bank heist which quickly turns sour and escalates into a hostage situation and stand-off with the police. As Sonny's motives for the robbery are slowly revealed and things become more complicated, the heist turns into a media circus.
Ace assassin Frank Kitchen is double crossed by gangsters and falls into the hands of rogue surgeon known as The Doctor who turns him into a woman. The hitman, now a hitwoman, sets out for revenge, aided by a nurse named Johnnie who also has secrets.