Joe, a young American soldier, is hit by a mortar shell on the last day of World War I. He lies in a hospital bed in a fate worse than death as a quadruple amputee who has lost his arms, legs, eyes, ears, mouth and nose. Unbeknown to his doctors, he remains conscious and able to think, thereby reliving his life through strange dreams and memories.
France, 1719. Louis 14th died four years ago, Philippe d'Orleans is the regent. He is a liberal and a libertine. His right-hand man, Dubois, an atheistic and cupid priest, as libertine as Philippe, tries to take advantage of a little rebellion lead by a Breton squire (Pontallec) and of the famine to become archbishop... Description of the life of the court in this period of transition where the French Revolution smoulders.
Based on Patrick DeWitt's novel, The Sisters Brothers revolves around the colourfully named gold prospector Hermann Kermit Warm, who's being pursued across 1000 miles of 1850s Oregon desert to San Francisco by the notorious assassins Eli and Charlie Sisters. Except Eli is having a personal crisis and beginning to doubt the longevity of his chosen career. And Hermann might have a better offer.