After a family visit, stressed businesswoman Senga Wilson (Madeleine Stowe) is driving with her rebellious daughter, Nat (Mischa Barton), down an ominous highway in the middle of the night. After they pick up a weird teenage hitchhiker (Bijou Phillips), their journey goes awry. Nat decides to give her mom the slip and runs off with the hitchhiker at a rest stop. In a desperate search to find her daughter, Senga learns that Nat has been drawn into an evil cult.
Five friends set out to a cabin in the woods for a fun weekend getaway that is, until extraterrestrial visitors turn it into a fight for their lives. The group is pulled from their reverie when a flickering object crashes deep in the woods. As they investigate, the friends stumble across an alien spacecraft, and its inhabitants have not arrived in peace.
After a man with extraordinary—and frighteningly destructive—telepathic abilities is nabbed by agents from a mysterious rogue corporation, he discovers he is far from the only possessor of such strange powers, and that some of the other “scanners” have their minds set on world domination, while others are trying to stop them.
When a straight-laced couple that has fun with a rowdy couple on vacation in Mexico return to the States, they discover that the crazy couple they met in Mexico followed them back home.
In the Harlem neighborhood of New York City, the Mafia steps in when a drug dealer quits his partner brother to lead a straight life with his girlfriend.
In the Iranian ghost-town Bad City, a place that reeks of death and loneliness, the townspeople are unaware they are being stalked by a lonesome vampire.
Three best friends and dedicated roleplayers take to the woods to reenact a dungeons and dragons-like scenario as a live action role-playing game. Trouble arises when a prop spellbook purchased from the internet ends up being a genuine grimoire and they unwittingly conjure up a blood-lusting succubus from hell.