Washington, D.C. psychologist Carol Bennell and her colleague Dr. Ben Driscoll are the only two people on Earth who are aware of an epidemic running rampant through the city. They discover an alien virus aboard a crashed space shuttle that transforms anyone who comes into contact with it into unfeeling drones while they sleep. Carol realizes her son holds the key to stopping the spread of the plague and she races to find him before it is too late.
The residents of a rural mining town discover that an unfortunate chemical spill has caused hundreds of little spiders to mutate overnight to the size of SUVs. It's then up to mining engineer Chris McCormack and Sheriff Sam Parker to mobilize an eclectic group of townspeople, including the Sheriff's young son, Mike, her daughter, Ashley, and paranoid radio announcer Harlan, into battle against the bloodthirsty eight-legged beasts.
After being around for centuries and now living in the modern age, vampire Adam (Tom Hiddleston) is a rockstar who cannot grow accustomed to the new modern world with all of its new technology. While he lives in Detroit, his wife Eve (Tilda Swinton) lives in Tangier, flourishing in the new world. But when she senses Adam's depression with society, she gets on a plane and goes to see him. Shortly after Eve gets there, her little sister, Ava (Mia Wasikowska), shows up after 87 years and disrupts the couple's idyll reunion.