Jose Luis is an executive at his parents underwear factory where his girlfriend Sylvia works on the shop floor. When Sylvia becomes pregnant, Jose Luis promises her that he will marry her, most likely against the wishes of his parents. Jose Luis' mother is determined to break her son's engagement to a girl from a lower-class family, and hires Raul, a potential underwear model and would-be bullfighter to seduce Sylvia.
Clear the runway for Derek Zoolander, VH1's three-time male model of the year. His face falls when hippie-chic "he's so hot right now" Hansel scooters in to steal this year's award. The evil fashion guru Mugatu seizes the opportunity to turn Derek into a killing machine. Its a well-designed conspiracy and only with the help of Hansel and a few well-chosen accessories can Derek make the world safe.
When we last saw male models Derek (Ben Stiller) and Hansel (Owen Wilson), they were enjoying the wonders of the “Derek Zoolander Center for Kids Who Can’t Read Good And Wanna Learn To Do Other Stuff Good Too,” and Mugatu (Will Ferrell) was behind bars. An unforeseen catastrophe strikes the Center and forces the duo into seclusion, living off the grid. Fifteen age-defying years later we find a still shamed Derek and Hansel leading isolated, separate lives, shut-out from the rest of the world.When each receives a special invitation to star in a major world fashion event in the ancient and mysterious city of Rome, they are unable to deny the allure of returning to their former glory and make their way back to civilization. While they struggle to find relevance in this strange new world of blogging, vlogging, and anti-fashion fashion, they are recruited to help stop a calculated and deadly plot that if not stopped, would destroy forever the hopes for fashion to return to its revered and glorious status. Only Derek and Hansel have the power to SAVE FASHION.