Samantha Caine, suburban homemaker, is the ideal mom to her 8 year old daughter Caitlin. She lives in Honesdale, PA, has a job teaching school and makes the best Rice Krispie treats in town. But when she receives a bump on her head, she begins to remember small parts of her previous life as a lethal, top-secret agent.
Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began – The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.