Josh Miller is a studious and responsible pre-med student entering college as a freshman. His wild, hard-partying roommate Cooper Frederickson, on the other hand, is a spoiled rich kid who never studies and spends his time getting drunk and ogling co-eds. Before long, Cooper's fun-filled lifestyle has corrupted Josh, and both are on the verge of flunking out.
Father and son, who are coroners, who receive a mysterious homicide victim with no apparent cause of death. As they attempt to identify the beautiful young "Jane Doe," they discover increasingly bizarre clues that hold the key to her terrifying secrets.