Two men wake up to find themselves shackled in a grimy, abandoned bathroom. As they struggle to comprehend their predicament, they discover a disturbing tape left behind by the sadistic mastermind known as Jigsaw. With a chilling voice and cryptic instructions, Jigsaw informs them that they must partake in a gruesome game in order to secure their freedom.
Bella Baxter is brought back to life by the brilliant and unorthodox scientist Dr. Godwin Baxter. Hungry for the worldliness she is lacking, Bella runs off with Duncan Wedderburn, a slick and debauched lawyer, on a whirlwind adventure across the continents.
After witnessing a bizarre, traumatic incident involving a patient, Dr. Rose Cotter starts experiencing frightening occurrences that she can't explain. As an overwhelming terror begins taking over her life, Rose must confront her troubling past in order to survive and escape her horrifying new reality.
After leaving Washington D.C. hospital, plastic surgeon Ben Stone heads for California, where a lucrative practice in Beverly Hills awaits. After a car accident, he's sentenced to perform as the community's general practitioner.
To foil a terrorist plot, an FBI agent undergoes facial transplant surgery to assume the identity of the criminal mastermind who murdered his only son, but the criminal wakes up prematurely and seeks revenge.
A bereaved Satanist couple kidnap a pregnant woman so they can use an ancient spellbook to put their dead grandson's spirit into her unborn child, but they end up summoning more than they bargained for.
The film centers on Dr. Marcus, a renowned psychiatrist who has selected 6 severe mentally ill and dangerous patients from the Spring Valley Mental Hospital to interview as part of research for his new book. As Dr. Marcus interviews each patient, one by one the horrors they have committed begin to unfold. However, Dr. Marcus soon learns that there is one patient who ties them all together - Patient Seven.