When a Spanish Jesuit goes into the South American wilderness to build a mission in the hope of converting the Indians of the region, a slave hunter is converted and joins his mission. When Spain sells the colony to Portugal, they are forced to defend all they have built against the Portugese aggressors.
When a well-known environmental researcher is murdered in the Amazon jungle, an arrogant photojournalist joins forces with a beautiful young activist to find out who is responsible. Along they way, they fall in love as they discover the men responsible for the killing would be more than willing to murder again if it will keep them quiet.
Hostiles takes place in 1892 and tells the story of an Army Captain who reluctantly agrees to escort a dying Cheyenne chief and his family back to tribal lands. On the journey, they meet a widow whose family was murdered on the plains and offer their help. As the former rivals make their way from an isolated Army outpost in New Mexico to the grasslands of Montana, their relationship moves from antagonism to compassion, demonstrating humans' capacity for change.