In September of 2001, Chloe, a college senior at a school in lower Manhattan, tests positive for HIV. Over the weeks that follow, she struggles to deal with her diagnosis, past trauma, and an uncertain future. As her estranged stepfather Doug attempts to reconnect and classmate Trevor shyly tries to gain her affection, Chloe pulls further away until making a terrifying discovery about one of her classmates.
Laura, in order to save her relationship from falling apart, goes to Sicily, where she meets Massimo. A dangerous man, the head of a mafia family, kidnaps her and gives her 365 days to fall in love with him.