A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.
Primatologist Davis Okoye shares an unshakable bond with George, the extraordinarily intelligent gorilla who has been in his care since birth. But a rogue genetic experiment gone awry transforms this gentle ape into a raging monster. As these newly created monsters tear across North America, destroying everything in their path, Okoye fights his way through an ever-changing battlefield, not only to halt a global catastrophe but to save the fearsome creature that was once his friend.