In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.
After graduating from Emory University in 1992, top student and athlete Christopher McCandless abandons his possessions, gives his entire $24,000 savings account to charity, and hitchhikes to Alaska to live in the wilderness.
During the course of an ordinary week in Hollywood, movie producer Ben must navigate his way through shark-infested waters as he struggles to complete his latest projects. A demanding studio boss demands extensive changes to a movie starring Sean Penn, while another chief won't greenlight a project unless star Bruce Willis shaves his beard. Meanwhile, Ben tries to reconcile with his wife and maintain a relationship with his young daughter.
A massage therapist looking to overcome her addictions and reconnect with her son, whose father is an anthropologist in South America studying the Yanomani people, moves in with a wealthy ex-client.
When Robin's daughter Lacy wants to buy an expensive guitar, Robin reminisces about the days when she was a teenager, asking her dad for her first car, an Olds Cutlass Supreme.
Alice Howland, happily married with three grown children, is a renowned linguistics professor who starts to forget words. When she receives a devastating diagnosis, Alice and her family find their bonds tested.
Massachusetts, 1892. An unmarried woman of 32 and a social outcast, Lizzie lives a claustrophobic life under her father's cold and domineering control. When Bridget Sullivan, a young maid, comes to work for the family, Lizzie finds a sympathetic, kindred spirit, and a secret intimacy soon blossoms into a wicked plan.
A young woman named Savannah Knoop spends six years pretending to be a transgender writer named JT Leroy, the made-up literary persona of her sister-in-law.
Three strong-willed women strive to forge their own paths amidst the wide-open plains of the American Northwest: a lawyer forced to subdue a troubled client; a wife and mother whose plans to construct her dream home reveal fissures in her marriage; and a lonely ranch hand who forms an ambiguous bond with a young law student.