Set in the "not-so-distant future", the crew of an international space station are set to return triumphantly to Earth, until someone starts killing the other crew members.
A repo man tries to deliver a repossessed Jaguar. He's captured by a bizarre family, straight out of the backwoods, who force him to fight in an illegal, bare-fist tournament run by an insane sheriff.
A deranged, misogynistic killer assaults a journalist. When he discovers that she survived the attack, he follows her to the hospital to finish her off.
The film centers on Dr. Marcus, a renowned psychiatrist who has selected 6 severe mentally ill and dangerous patients from the Spring Valley Mental Hospital to interview as part of research for his new book. As Dr. Marcus interviews each patient, one by one the horrors they have committed begin to unfold. However, Dr. Marcus soon learns that there is one patient who ties them all together - Patient Seven.
A detective investigates a series of murders that he begins to suspect are being committed by a woman involved in prostitution and narcotics trafficking.