Five strangers board a train and are joined by a mysterious fortune teller who offers to read their Tarot cards. Five separate stories unfold: An architect returns to his ancestoral home to find a werewolf out for revenge; a doctor discovers his new wife is a vampire; a huge plant takes over a house; a musician gets involved with voodoo; an art critic is pursued by a disembodied hand.
The first remake of the paranoid infiltration classic moves the setting for the invasion, from a small town to the city of San Francisco and starts as Matthew Bennell notices that several of his friends are complaining that their close relatives are in some way different. When questioned later they themselves seem changed, as they deny everything or make lame excuses. As the invaders increase in number they become more open and Bennell, who has by now witnessed an attempted "replacement", realises that he and his friends must escape or suffer the same fate. But who can he trust to help him and who has already been snatched?
When an outbreak hits, Aidan barricades himself inside his apartment and starts rationing food. His complex is overrun by infected Screamers, and with the world falling apart into chaos, he is left completely alone fighting for his life.