Frank O'Brien, a petty thief, and his 7-year-long girlfriend Roz want to put an end to their unsteady lifestyle and just do that last job, which involves stealing a valuable painting. Frank takes Roz to an island on the coast of New England, where he wants to sell the painting and also hopes that their sagging relationship will get a positive push back up. Not everything goes as planned.
Legendary undercover DEA agent Charlie Mayough has suddenly lost his nerves of steel. On the verge of a career-induced mental breakdown, and in complete fear of trigger-happy Mafia leader Fulvio Nesstra, Charlie seeks psychiatric help and finds himself relying on the support of an unstable therapy group and nurse Judy just to get through his work.
Birdee Pruitt has been humiliated on live television by her best friend, Connie, who's been sleeping with Birdee's husband, Bill. Birdee tries starting over with her daughter, Bernice, by returning to her small Texas hometown, but she's faced with petty old acquaintances who are thrilled to see Birdee unhappy -- except for her friend Justin. As he helps Birdee get back on her feet, love begins to blossom.
Unlucky in love, chemist Paul Matthews visits gypsy Madame Rosa for help. Quickly realizing he is a hopeless nerd, she gifts him with Love Potion No. 8, which makes anyone who wears it irresistible to the opposite sex for four hours. Paul and animal psychologist coworker Diane Farrow decide to test it on themselves. The awkward pair suddenly find themselves alluring to anyone they approach, but soon realize they are most attracted to each other.
Sally and Gillian Owens, born into a magical family, have mostly avoided witchcraft themselves. But when Gillian's vicious boyfriend, Jimmy Angelov, dies unexpectedly, the Owens sisters give themselves a crash course in hard magic. With policeman Gary Hallet growing suspicious, the girls struggle to resurrect Angelov -- and unwittingly inject his corpse with an evil spirit that threatens to end their family line.
After getting into a car accident while drunk on the day of her sister's wedding, Gwen Cummings is given a choice between prison or a rehab center. She chooses rehab, but is extremely resistant to taking part in any of the treatment programs they have to offer, refusing to admit that she has an alcohol addiction.
A transit worker pulls commuter Peter off railway tracks after he's mugged, but—while he's in a coma—his family mistakenly thinks she's Peter's fiancée, and she doesn't correct them. Things get more complicated when she falls for his brother, who's not quite sure that she's who she claims to be.
Ben Holmes, a professional book-jacket blurbologist, is trying to get to Savannah for his wedding. He just barely catches the last plane, but a seagull flies into the engine as the plane is taking off. All later flights are cancelled because of an approaching hurricane, so he is forced to hitch a ride in a Geo Metro with an attractive but eccentric woman named Sara.
When the local FBI office receives a letter from a terrorist known only as 'The Citizen', it's quickly determined that he's planning his next act at the Miss America beauty pageant. Because tough-as-nails Gracie Hart is the only female Agent at the office, she's chosen to go undercover as the contestant from New Jersey.
Young Tommy Hudler decides to become a security systems salesman, and is an instant success. Everything seems to be going great until he discovers there's more to this business and his boss Heinrich than he previously suspected.