The best part of any marriage is consummating it. However after 3 months of a sexless marriage Dan, in a moment of weakness, finds himself in the throws of casual sex with another woman. Dan decides the only way to morally rectify this is of course to get his wife to cheat on him and thus he sets out to find the right man to put the hurt on his old lady.
Norman Reedus stars as Harry Odum, a henpecked, 18-year-old momma's boy in Youngstown, Ohio, who -- with his violent temper -- impresses a local boss of the Jewish Mafia. Soon he's found his calling as a hit man alongside his crack addict partner Arnie Finklestein (Adrien Brody), and he discovers that his rage and complicated psychosis fuel his murderous abilities. Harry also falls for the organization's limping, Hungarian-born maid Iris (Elina Lowensohn), a romance complicated by Harry's Oedipal, sexual relationship with his domineering mother Kate (Deborah Harry).
Trust Me follows flailing Hollywood agent Howard, who seemingly strikes gold after signing the next big child star. What results is an unexpected ride through the nasty inner workings of Hollywood, as Howard desperately tries to make it in an industry that has no interest in recognizing his bumbling but ultimately genuine nature.
Steve Coogan, an arrogant actor with low self-esteem and a complicated love life, is playing the eponymous role in an adaptation of "The Life and Opinions of Tristram Shandy, Gentleman" being filmed at a stately home. He constantly spars with actor Rob Brydon, who is playing Uncle Toby and believes his role to be of equal importance to Coogan's.