Trust Me follows flailing Hollywood agent Howard, who seemingly strikes gold after signing the next big child star. What results is an unexpected ride through the nasty inner workings of Hollywood, as Howard desperately tries to make it in an industry that has no interest in recognizing his bumbling but ultimately genuine nature.
Steve Coogan, an arrogant actor with low self-esteem and a complicated love life, is playing the eponymous role in an adaptation of "The Life and Opinions of Tristram Shandy, Gentleman" being filmed at a stately home. He constantly spars with actor Rob Brydon, who is playing Uncle Toby and believes his role to be of equal importance to Coogan's.
A radio journalist and his technician get in over their heads when they hatch a scheme to fake their own kidnapping during a rebel uprising in South America and hide out in New York instead.
Veronica is a white-bread beauty searching for a good man in Los Angeles. While slam dancing at a Halloween rave, she meets Abel, a sensitive poet. Then she meets Zed, a supersexy tattooed drummer with incredible biceps. Who will she choose? Does she go for true love or cheap sex? She can't decide so she chooses both. But after managing to nurture a picture-perfect threesome, along comes Ernest, a rich movie director with deep baby blues that sweep Veronica off her feet. What's a girl to do now?
Lawrence, an aging, lonely civil servant falls for Gina, an enigmatic young woman. When he takes her to the G8 Summit in Reykjavik, however, their bond is tested by Lawrence's professional obligations.
A submarine crew, a feared pack of forest bandits, a famous surgeon, and a battalion of child soldiers all get more than they bargained for as they wend their way toward progressive ideas on life and love.