Samuel Salomon, a literature professor, has been off work for almost a year after the tragic death of his girlfriend. Samuel has been suffering from a recurring nightmare in which a woman is brutally murdered in a strange ritual. Suddenly, the same woman who appears every night in his dreams is found dead in exactly the same circumstances. Samuel sneaks into the crime scene and there he meets Rachel who has also dreamed about the murder. Together, they will do whatever they can to discover the identity of the mystery woman, entering a terrifying world controlled by the figures who have inspired artists throughout time: the Muses.
Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.