Teenage Mary Cummings, who has "been Born Again her whole life," is about to enter her senior year at American Eagle Christian High School near Baltimore with her Fundamentalist Christian friends Hilary Faye and Veronica, the three of whom have formed a girl group called the Christian Jewels. Everything seems perfect—until Mary’s "perfect Christian boyfriend" Dean tells her, as they’re swimming underwater, that he thinks he's gay.
One day at work, unsuccessful puppeteer Craig finds a portal into the head of actor John Malkovich. The portal soon becomes a passion for anybody who enters its mad and controlling world of overtaking another human body.