Swackhammer, an evil alien theme park owner, needs a new attraction at Moron Mountain. When his gang, the Nerdlucks, heads to Earth to kidnap Bugs Bunny and the Looney Tunes, Bugs challenges them to a basketball game to determine their fate. The aliens agree, but they steal the powers of NBA basketball players, including Larry Bird and Charles Barkley -- so Bugs gets some help from superstar Michael Jordan.
The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.
When Quinn, a grouchy pilot living the good life in the South Pacific, agrees to transfer a savvy fashion editor, Robin, to Tahiti, he ends up stranded on a deserted island with her after their plane crashes. The pair avoid each other at first, until they're forced to team up to escape from the island -- and some pirates who want their heads.
Bill Mitchell is the philandering and distant President of the United States. Dave Kovic is a sweet-natured and caring Temp Agency operator, who by a staggering coincidence looks exactly like the President. As such, when Mitchell wants to escape an official luncheon, the Secret Service hires Dave to stand in for him. Unfortunately, Mitchell suffers a severe stroke whilst having sex with one of his aides, and Dave finds himself stuck in the role indefinitely. The corrupt and manipulative Chief of Staff, Bob Alexander, plans to use Dave to elevate himself to the White House - but unfortunately, he doesn't count on Dave enjoying himself in office, using his luck to make the country a better place, and falling in love with the beautiful First Lady...