Jon Lansdale is a comic book artist who loses his right hand in a car accident. The hand was not found at the scene of the accident, but it soon returns by itself to follow Jon around, and murder those who anger him.
A city cop is assigned to solve a bizarre set of violent murders where it appears that the victims were killed by animals. In his pursuit he learns of an Indian legend about wolf spirits.
New York City detective Daniel Ciello agrees to help the United States Department of Justice help eliminate corruption in the police department, as long as he will not have to turn in any close friends. In doing so, Ciello uncovers a conspiracy within the force to smuggle drugs to street informants