The anime centers on four girls at the full bloom of their youth, working hard to achieve their dreams as they struggle valiantly. In Japanese entertainment, Maesetsu! refers to an introductory talk or explanation addressed to the audience before the broadcast of television programs, usually performed by assistant directors and particularly comedians in variety or comedy shows.
Seton Academy, a school full of animals where, thanks to population decline, there are fewer humans than any other creature. Mazama Jin, an animal hater and the only human male in his class, falls in love with Hino Hitomi, the only female human, the moment he lays eyes her. However he soon finds himself entangled with various other creatures after he reluctantly joins the 'pack' of Lanka the wolf, the only other member of her pack.