In the isolated desert of Winslow, Arizona at NASA’s Moon Base Simulator, three eager astronauts—Skip, Rook and their leader Cap—attempt to qualify for their first lunar mission. They encounter many obstacles including loneliness, self-doubt and their own incompetence. In spite of it all, they remain determined to prove they have the right stuff to reach the moon.
Based on Patrick DeWitt's novel, The Sisters Brothers revolves around the colourfully named gold prospector Hermann Kermit Warm, who's being pursued across 1000 miles of 1850s Oregon desert to San Francisco by the notorious assassins Eli and Charlie Sisters. Except Eli is having a personal crisis and beginning to doubt the longevity of his chosen career. And Hermann might have a better offer.