Marcus Burnett is a hen-pecked family man. Mike Lowry is a foot-loose and fancy free ladies' man. Both are Miami policemen, and both have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.
A hotshot Washington criminal lawyer becomes the target of a rogue security executive videotaped in the act of murdering a congressman when the incriminating tape is surreptitiously slipped into his shopping bag by the videographer, who is fleeing the executive's assassins.
Talented but unproven stock car driver Cole Trickle gets a break and with the guidance of veteran Harry Hogge turns heads on the track. The young hotshot develops a rivalry with a fellow racer that threatens his career when the two smash their cars. But with the help of his doctor, Cole just might overcome his injuries-- and his fear.
FBI chemical warfare expert Stanley Goodspeed is sent on an urgent mission with a former British spy, John Patrick Mason, to stop Gen. Francis X. Hummel from launching chemical weapons on Alcatraz Island into San Francisco. Gen. Hummel demands $100 million in war reparations to be paid to the families of slain servicemen who died on covert operations. After their SEAL team is wiped out, Stanley and John deal with the soldiers on their own.
Caroline and Lloyd are a married couple constantly at each other's throats, masters at crafting acid-tongued barbs at the other's expense. Indeed, they are so obsessed with belittling each other that they never stop -- not even at gunpoint. The gunman is Gus, a thief on the run from the police, who kidnaps the couple as an insurance policy, planning to use their home as a hideout. But their incessant bickering proves more than Gus bargained for, forcing him -- for the sake of his own sanity -- into the unenviable role of peacemaker. To make things even worse for Gus, he discovers that he has taken the couple hostage the night of their big Christmas party, and the guests are already on the way. Not wanting to leave Lloyd and Caroline unattended, Gus opts to attend the party, pretending to be the couple's marriage counselor. This naturally leads to a series of comic confusions, as the hostage crisis and marital tensions head towards their inevitable conclusion.
Out-of-control, trash-talking buddy cops Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force reunite, and bullets fly, cars crash and laughs explode as they pursue a whacked-out drug lord from the streets of Miami to the barrios of Cuba. But the real fireworks result when Marcus discovers that playboy Mike is secretly romancing Marcus’ sexy sister.