A collection of intersecting short stories set in early 1980s Los Angeles, depicts a week in the lives of an assortment of socially alienated, mainly well-off characters who numb their sense of emptiness with casual sex, violence, and drugs.
A convert to Islam sends the U.S. government a tape showing him in three nondescript storage rooms, each of which may contain a nuclear bomb set to detonate in less than a week. Helen Brody, an FBI agent in L.A., is tasked with finding the bombs while a CIA "consultant", known as H, interrogates the suspect who has allowed himself to be caught. The suspect, whose wife and children have left him and disappeared, seems to know exactly what the interrogation will entail. Even as H ratchets up the pressure, using torture over Brody's objection, the suspect doesn't crack. Should H do the unthinkable, and will Brody acquiesce? Is any Constitutional principle worth possible loss of life?
Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
Cast: Adrien Brody, Sarah Polley, David Hewlett
Directed by Vincenzo Natali
Script: Vincenzo Natali, Antoinette Terry Bryant
Producer: Guillermo del Toro