Yuta Okkotsu is a nervous high school student who is suffering from a serious problem—his childhood friend Rika has turned into a curse and won't leave him alone. Since Rika is no ordinary curse, his plight is noticed by Satoru Gojo, a teacher at Jujutsu High, a school where fledgling exorcists learn how to combat curses. Gojo convinces Yuta to enroll, but can he learn enough in time to confront the curse that haunts him?
Yūji Itadori is a boy with tremendous physical strength, though he lives a completely ordinary high school life. One day, to save a friend who has been attacked by Curses, he eats a finger of Ryōmen Sukuna, taking the Curse into his own soul. From then on, he shares one body with Sukuna. Guided by the most powerful of sorcerers, Satoru Gojō, Itadori is admitted to the Tokyo Metropolitan Technical High School of Sorcery, an organization that fights the Curses... and thus begins the heroic tale of a boy who became a Curse to exorcise a Curse, a life from which he could never turn back.